In 1962 she began a string of successful Billboard Hot 100 Top 10 hits: "Slow Twistin'" (with Chubby Checker) (#3), "Mashed Potato Time" (#2), "Gravy (For My Mashed Potatoes)" (#9), "Ride" (#5) and "Do the Bird" (#10).[1] Both "Mashed Potato Time" and "Ride" each sold over one million copies, and were awarded gold discs.[2] "Do the Bird" provided her only entry in the UK Singles Chart, where it peaked at #46 in April 1963.[3] In 1967, she married record producer Kenny Gamble and has since recorded under the name Dee Dee Sharp-Gamble.[1]

She had a brief career resurgence during the disco era: as a member of the Philadelphia International All Stars (which also included Lou Rawls, Billy Paul, Teddy Pendergrass, The O'Jays and Archie Bell) she had a minor hit with "Let's Clean Up the Ghetto."

In 1980 she spent four weeks at number one on the Hot Dance Club Play chart with "Breaking and Entering" / "Easy Money," from her album Dee Dee.

More recent appearances included a performance at Pontins in the UK for the Northern Soul Show, and at the 2008 Detroit Jazz Festival. In May 2009, she appeared in Belgium at the Salle De L'Hotel de Ville
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